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KMID : 0438420140210030217
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Korean Journal of Bone Metabolism
2014 Volume.21 No. 3 p.217 ~ p.222
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Increase in the Serum Parathyroid Hormone Level During a Bisphosphonate Drug Holiday
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Song Yoon-Kyung
Kim Jeong-Min
Park Sun-Jin
Lee Seong-Kyu
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Abstract
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After discontinuation of bisphosphonate therapy, an antiresorptive effect and antifracture protection persist for an undefined period. Patients are encouraged to continue calcium and vitamin D supplementation, during a bisphosphonate drug holiday. However, assessment of adequate calcium intake during the bisphosphonate drug holiday is difficult. Therefore, we measured the serum intact parathyroid hormone (PTH) level as a surrogate marker. A premenopausal woman discontinued bisphosphonate therapy, after 7.5 years of treatment. Two months later, blood calcium and phosphorus levels were normal, serum 25-hydroxyvitamin D level was 31.3 ng/mL, but serum PTH level had increased to 94.9 pg/mL. The elemental calcium supplement dose was increased to 600 mg/day, with no change in the cholecalciferol dose (400 IU). Her serum PTH levels decreased to 49.1 after 4 months and 32.9 pg/mL after 5 months. The serum PTH level may be helpful in assessing adequate calcium intake during a bisphosphonate drug holiday.
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KEYWORD
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Bisphosphonate, Calcium, Parathyroid hormone, Vitamin D
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